Prognostic value of presepsin in adult patients with sepsis: Systematic review and metaanalysis

Presepsin is a novel biomarker to diagnose sepsis but its prognostic value has not been comprehensively reviewed. We conducted this meta-analysis to evaluate the mortality prediction value of presepsin in sepsis.
We searched comprehensive electronic databases from PubMed, EMBASE, and Cochrane Library through September 2017 using the key words of (`presepsin' or `sCD14-ST' or `soluble CD14 subtype') and (`sepsis' or `septic shock') and (`prognosis' or `prognostic value' or `prognostic biomarker' or `mortality'). We extracted the presepsin levels in survivors and non-survivors from each individual study and evaluated the standardized mean difference (SMD) using a web-based meta-analysis with the R statistical analysis program.