Novel Diagnostics and Therapeutics in Sepsis

Abstract: Sepsis management demands early diagnosis and timely treatment that includes source con- trol, antimicrobial therapy, and resuscitation. Currently employed diagnostic tools are ill-equipped to rapidly diagnose sepsis and isolate the offending pathogen, which limits the ability to offer tar- geted and lowest-toxicity treatment. Cutting edge diagnostics and therapeutics in development may improve time to diagnosis and address two broad management principles: (1) source control by removing the molecular infectious stimulus of sepsis, and (2) attenuation of the pathological immune response allowing the body to heal. This review addresses novel diagnostics and therapeutics and their role in the management of sepsis.

Keywords: sepsis; novel; diagnosis; diagnostics; therapy; therapeutic; treatment; management; biomarkers; innovation