A new marker for the diagnosis of sepsis: Presepsin
Sepsis is a clinical syndrome that complicates severe infection. It is characterized by the
cardinal signs of inflammation (vasodilatation, leukocyte accumulation, increased
microvascular permeability) occurring in tissues which are remote from the infection.
The
clinical definitions of sepsis are basically nonspecific, often resulting in the delay of the
diagnosis. During the last decade, a variety of different molecules have been suggested as
clinical biomarkers in sepsis, most of which are still in experimental stage. However, some
have came into use in clinical practice and have evolved as valuable tools for diagnosis,
therapy monitoring, and outcome prediction.
Department of Medical Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey