Presepsin and fetuin-A dyad for the diagnosis of proven sepsis in preterm neonates

Despite recent advances in neonatal medicine in the last years, sepsis is still a leading cause of mortality and morbidity among hospitalized infants in neonatal intensive care units (NICU) [1–3]. Nearly two-thirds of extremely low birth weight (ELBW) infants experience more than one episode of suspected or culture-proven late-onset sepsis (LOS) during hospitalization [1]. Neurodevelopmental impairment and mortality are substantially higher in ELBW infants with sepsis, even if without meningitis, compared with those not experienced infections [1].