Discriminatory ability and prognostic evaluation of presepsin for sepsis-related acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) is characterized by acute respiratory failure with severe hypoxemia and diffuse pulmonary infiltrates, which may occur after severe pulmonary and systemic injuries of septic and non-septic causes1,2. Despite the advances in supportive care strategies and significant efforts invested in research and clinical trials for ARDS, its mortality rate remains high, especially among patients with sepsis3,4. It may be
favorable to characterize between septic and non-septic causes of ARDS because there is evidence to suggest that discrimination of these two subgroups might lead to improvements in future research and management of ARDS5,6. Early identification of sepsis-related or non-sepsis-related ARDS is challenging because patients with originally non-septic causes treated in intensive care units (ICUs) frequently acquire bacterial infection.