Presepsin (soluble CD14 subtype) Is Secreted from Human Monocytes after Phagocytosis
INTRODUCTION:
Presepsin is a subtype of soluble CD14, which is a receptor for
lipopolysaccharide (LPS)/LPS-binding protein complexes and is expressed
on the myelomonocytic cell surface. Recently, it has been shown to be a
useful biomarker for assessing the severity of sepsis and has come into use
in the field of critical care medicine. However, the precise mechanism
involved in its production in human is yet to be ascertained. Therefore, we
performed in vitro analyses to determine the main sources of presepsin and
the mechanism of presepsin production in humans. We also performed a
retrospective cohort study to determine the clinical relevance of presepsin
in the diagnosis of bacteremia or other complications after allogeneic stem
cell transplantation (allo-SCT) because, so far, only one study has analyzed
the utility of presepsin as a biomarker for myelosuppressed patients after
chemotherapies.