Validation of the New Biomarker Presepsin for Diagnosis of Sepsis
Introduction:
There are various adjunctive biomarkers for diagnosis of infection. These circulating biomarkers are useful not only for diagnosis of sepsis but also as a guide for an antimicrobial strategy in sepsis patients. Presepsin is a soluble N-terminal fragment protein of CD14, which is released from activated phagocytic cells. Several studies have demonstrated the usefulness of presepsin for diagnosis of infection. However, precise evaluation of presepsin has not yet been done. We conducted this study to clarify the validity of presepsin for diagnosis of infection and for evaluation of the severity of sepsis.
There are various adjunctive biomarkers for diagnosis of infection. These circulating biomarkers are useful not only for diagnosis of sepsis but also as a guide for an antimicrobial strategy in sepsis patients. Presepsin is a soluble N-terminal fragment protein of CD14, which is released from activated phagocytic cells. Several studies have demonstrated the usefulness of presepsin for diagnosis of infection. However, precise evaluation of presepsin has not yet been done. We conducted this study to clarify the validity of presepsin for diagnosis of infection and for evaluation of the severity of sepsis.